KSM-66

Best for

Stay asleep through the night

Likely strong benefit · 120–600 mg/day for 10 weeks · 1 meta-analysis , n=339

36 papers · 14 claims · 137 outcomes scored · 13 positive

Outcomes

What ksm-66 actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Improve everyday quality of life Likely strong benefit

Fewer days where health problems dictate what you can and cannot do.

11 meta-analyses n=732 1–600 mg 8–12 wk #1/61

32226684·33600918·36447681·36937128 +7 more

large

11 meta-analyses n=732 Meta-analyzed I²=93%

1–600 mg

8–12 wk

#1 /61

Stay asleep through the night Likely strong benefit

Fewer wake-ups and more unbroken hours of real rest.

2 meta-analyses n=339 120–600 mg 10 wk #1/15

31728244·34559859

large

2 meta-analyses n=339 Meta-analyzed

120–600 mg

10 wk

#1 /15

Fall asleep faster Likely strong benefit

Shrinks the gap between hitting the pillow and actually sleeping.

2 meta-analyses n=339 120–600 mg 10 wk #2/19

31728244·34559859

large

2 meta-analyses n=339 Meta-analyzed

120–600 mg

10 wk

#2 /19

Lift and steady your mood Large effect, needs confirmation

Good days come more often and bad ones feel less heavy.

2 RCTs n=90 125–600 mg 9–12 wk #2/20

23439798·40875185

large

2 RCTs n=90

125–600 mg

9–12 wk

#2 /20

Reduce daily stress Promising early signal

Everyday pressure stops running your nervous system hot.

9 meta-analyses n=1.1k 0–6000 mg 4–12 wk #2/41

23439798·27055824·32021735·38931168 +5 more

moderate

9 meta-analyses n=1.1k Meta-analyzed I²=93%

0–6000 mg

4–12 wk

#2 /41

Build stronger muscles Promising early signal

Higher one-rep max, stronger grip, and more force from every muscle group.

4 meta-analyses n=153 240–600 mg 4–8 wk #8/38

33670194·38988644·26609282·39954269

moderate

4 meta-analyses n=153 Meta-analyzed

240–600 mg

4–8 wk

#8 /38

Improve overall sleep quality Likely modest benefit

Deeper, less interrupted nights that leave you recharged by morning.

7 meta-analyses n=596 120–700 mg 4–12 wk #2/37

31728244·32021735·32226684·34559859 +3 more

small

7 meta-analyses n=596 Meta-analyzed I²=90%

120–700 mg

4–12 wk

#2 /37

Lower day-to-day anxiety Likely modest benefit

The background hum of worry that colors everything gets quieter.

7 meta-analyses n=500 125–600 mg 8–12 wk #3/48

23439798·24330893·31728244·32021735 +3 more

small

7 meta-analyses n=500 Meta-analyzed

125–600 mg

8–12 wk

#3 /48

Ease anxiety in older adults Likely modest benefit

Quiets the health worries and body tension that build with age.

7 meta-analyses n=500 125–600 mg 8–12 wk #3/45

23439798·24330893·31728244·32021735 +3 more

small

7 meta-analyses n=500 Meta-analyzed

125–600 mg

8–12 wk

#3 /45

Reduce pre-competition anxiety Likely modest benefit

Quiets the overthinking that hijacks execution right before you compete.

7 meta-analyses n=500 125–600 mg 8–12 wk #3/45

23439798·24330893·31728244·32021735 +3 more

small

7 meta-analyses n=500 Meta-analyzed

125–600 mg

8–12 wk

#3 /45

Ease your body's stress response Faint early signal

Heart rate, sweating, and tension spike less under pressure.

1 RCT n=90 125 mg 12 wk #1/2

40875185

small

1 RCT n=90

125 mg

12 wk

#1 /2

Strengthen your memory Faint early signal

Names, conversations, faces, and details stick instead of dissolving.

2 RCTs n=53 225–500 mg 4–8 wk #2/42

24330893·38931168

small

2 RCTs n=53

225–500 mg

4–8 wk

#2 /42

Strengthen planning and mental control Faint early signal

Organize priorities, switch tasks, and catch mistakes more easily.

1 RCT n=53 250–500 mg 8 wk #7/28

24330893

small

1 RCT n=53

250–500 mg

8 wk

#7 /28

Sharpen social processing Not enough research

Conversations and everyday interactions feel more natural and fluid.

1 RCT n=53 250–500 mg 8 wk

24330893

—

1 RCT n=53

250–500 mg

8 wk

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Improve everyday quality of life Likely strong benefit	large	11 meta-analyses n=732 Meta-analyzed	1–600 mg	8–12 wk	#1/61
Stay asleep through the night Likely strong benefit	large	2 meta-analyses n=339 Meta-analyzed	120–600 mg	10 wk	#1/15
Fall asleep faster Likely strong benefit	large	2 meta-analyses n=339 Meta-analyzed	120–600 mg	10 wk	#2/19
Lift and steady your mood Large effect, needs confirmation	large	2 RCTs n=90	125–600 mg	9–12 wk	#2/20
Reduce daily stress Promising early signal	moderate	9 meta-analyses n=1.1k Meta-analyzed	0–6000 mg	4–12 wk	#2/41
Build stronger muscles Promising early signal	moderate	4 meta-analyses n=153 Meta-analyzed	240–600 mg	4–8 wk	#8/38
Improve overall sleep quality Likely modest benefit	small	7 meta-analyses n=596 Meta-analyzed	120–700 mg	4–12 wk	#2/37
Lower day-to-day anxiety Likely modest benefit	small	7 meta-analyses n=500 Meta-analyzed	125–600 mg	8–12 wk	#3/48
Ease anxiety in older adults Likely modest benefit	small	7 meta-analyses n=500 Meta-analyzed	125–600 mg	8–12 wk	#3/45
Reduce pre-competition anxiety Likely modest benefit	small	7 meta-analyses n=500 Meta-analyzed	125–600 mg	8–12 wk	#3/45
Ease your body's stress response Faint early signal	small	1 RCT n=90	125 mg	12 wk	#1/2
Strengthen your memory Faint early signal	small	2 RCTs n=53	225–500 mg	4–8 wk	#2/42
Strengthen planning and mental control Faint early signal	small	1 RCT n=53	250–500 mg	8 wk	#7/28
Sharpen social processing Not enough research		1 RCT n=53	250–500 mg	8 wk	—

Buy well

Recommended KSM-66 products

Real products that dose KSM-66 where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate KSM-66 dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

hepatotoxicity (drug-induced liver injury) severe

adrenal hypofunction (adrenal insufficiency) severe

adrenal_insufficiency / HPA axis suppression severe

thyrotoxicosis moderate

gastrointestinal discomfort (poor digestion / abdominal bloating) moderate

cough and cold moderate

acute dystonia (cervical dystonia and oculogyric crisis) moderate

Cushingoid features (facial puffiness) moderate

Sources

Generated August 14, 2026

KSM-66

What ksm-66 actually does, by outcome

Recommended KSM-66 products

Adverse events and known drug interactions

More evidence for KSM-66

Focus & memory: evidence map across 45 supplements

Sleep: evidence map across 37 supplements

Stress: evidence map across 46 supplements

KSM-66

Recommended KSM-66 products

More evidence for KSM-66

NewFocus & memory: evidence map across 45 supplements

NewSleep: evidence map across 37 supplements

NewStress: evidence map across 46 supplements

Focus & memory: evidence map across 45 supplements

Sleep: evidence map across 37 supplements

Stress: evidence map across 46 supplements