Nattokinase

Best for

Clear old clots more efficiently

Faint early signal · 1 study , n=24

7 papers · 2 claims · 32 outcomes scored · 2 positive

Outcomes

What nattokinase actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect size Evidence Dose Weeks Rank

Lower your blood pressure Likely modest benefit

Brings down both systolic and diastolic, especially when baseline runs high.

4 meta-analyses n=388 3.97–8000 mg 8 wk #7/81

18971533·27785095·39076715·37483751

small

4 meta-analyses n=388 Meta-analyzed I²=78%

3.97–8000 mg

8 wk

#7 /81

Clear old clots more efficiently Faint early signal

Your body breaks down spent clot material faster instead of letting it linger.

1 RCT n=24 2000 other —

26109079

small

1 RCT n=24

2000 other

—

Outcome	Effect	Evidence	Dose	Weeks	Rank
Lower your blood pressure Likely modest benefit	small	4 meta-analyses n=388 Meta-analyzed	3.97–8000 mg	8 wk	#7/81
Clear old clots more efficiently Faint early signal	small	1 RCT n=24	2000 other	—	—

Risk profile

Adverse events and known drug interactions

Safety events

cerebellar hemorrhage (intracerebral hemorrhage) severe

pulmonary haemorrhage

hemorrhage

thrombosis

abdominal discomfort

stroke (ischemic or hemorrhagic)

Drug interactions

Heparin (Unfractionated And Related GAGs) major additive

Fondaparinux major additive

Enoxaparin major additive

other major increases toxicity

Dexamethasone moderate decreases concentration

Sources

Generated August 14, 2026

Nattokinase

What nattokinase actually does, by outcome

Adverse events and known drug interactions

More evidence for Nattokinase

Threads That Melt Knots: The True Story of Nattokinase

Best Supplements to Clear Old Clots More Efficiently (2026)

Arginine

Black Garlic

Caffeine

flavan-3-ols

Nattokinase

More evidence for Nattokinase

NewThreads That Melt Knots: The True Story of Nattokinase

NewBest Supplements to Clear Old Clots More Efficiently (2026)

NewArginine

NewBlack Garlic

NewCaffeine

Newflavan-3-ols

Threads That Melt Knots: The True Story of Nattokinase

Best Supplements to Clear Old Clots More Efficiently (2026)

Arginine

Black Garlic

Caffeine

flavan-3-ols