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Hypericum

Hypericum

Evidence status

Limited evidence to recommend for any consumer outcome yet.

2 papers · 3 claims · 2 outcomes scored

Outcomes

What hypericum actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Ease depression symptoms Not enough research
1 RCT n=— 350 mg 8 wk —
Ease winter depression symptoms Not enough research
1 RCT n=— 350 mg 8 wk —
Ease depression tied to chronic pain Not enough research
1 RCT n=— 350 mg 8 wk —

Risk profile

Adverse events and known drug interactions

Safety events

abdominal distension moderate
diarrhoea moderate
changes in sleeping habits mild
headache
fatigue
no cytotoxicity observed (in vitro)

Drug interactions

Cyclosporine major decreases concentration
Pentobarbital major increases effect
Diazepam major increases effect
Indinavir major decreases concentration
Ethinyl Estradiol major decreases concentration
Norethindrone major decreases concentration
Digoxin major decreases concentration
Irinotecan major unknown
Alfentanil major decreases concentration
Midazolam major decreases concentration

Sources

  1. 1. Hypericum extract versus imipramine or placebo in patients with moderate depression: randomised multicentre study of treatment for eight weeks. (1999) ↑
  2. 2. The Effectiveness of Herbal Medicines on Cyclic Mastalgia: A Systematic Review on Meta-analysis. (2022) ↑

Generated August 14, 2026

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