Monacolin
Best for
Lower bad and total cholesterol
Proven strong benefit · 4–200 mg/day for 4–13 weeks · 1 meta-analysis , n=896
5 papers · 2 claims · 12 outcomes scored · 2 positive
Outcomes
What monacolin actually does, by outcome
Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.
Outcome Effect size Evidence Dose Weeks Rank
Lower bad and total cholesterol Proven strong benefit
Cuts the cholesterol that builds into artery plaque over time.
5 meta-analyses n=896 4–200 mg 4–13 wk #1/103
5 meta-analyses
n=896
Meta-analyzed
4–200 mg
4–13 wk
#1 /103
| Outcome | Effect | Evidence | Dose | Weeks | Rank |
|---|---|---|---|---|---|
| Lower bad and total cholesterol Proven strong benefit | | 5 meta-analyses n=896 Meta-analyzed | 4–200 mg | 4–13 wk | #1/103 |
| Raise good cholesterol levels Proven modest benefit | | 5 meta-analyses n=862 Meta-analyzed | 5–200 mg | 4–13 wk | #3/71 |
Risk profile
Adverse events and known drug interactions
Safety events
headache mild
flatulence mild
muscle pain (myalgia) mild
muscle weakness mild
gastrointestinal upset / dyspepsia mild
myalgia
dizziness
reduced appetite
Co-studied with
Supplements that share evidence with monacolin
-
Coq10 4 shared outcomes · d=0.85 -
Grape 4 shared outcomes · d=0.85 -
Olive 4 shared outcomes · d=0.85 - Vitaminb5 Group 4 shared outcomes · d=0.85
-
Vitaminb6 4 shared outcomes · d=0.85 -
Vitaminb2 4 shared outcomes · d=0.85 -
Vitaminb1 4 shared outcomes · d=0.85 -
Vitaminb7 4 shared outcomes · d=0.85 -
Vitaminb12 4 shared outcomes · d=0.85 -
Vitaminb9 4 shared outcomes · d=0.85
Sources
- 1. Effect of red yeast rice combined with antioxidants on lipid pattern, hs-CRP level, and endothelial function in moderately hypercholesterolemic subjects. (2016) ↑
- 2. Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial. (2017) ↑
- 3. Evaluation the effects of red yeast rice in combination with statin on lipid profile and inflammatory indices; a randomized clinical trial. (2022) ↑
- 4. Lipid-lowering, antihypertensive, and antithrombotic effects of nattokinase combined with red yeast rice in patients with stable coronary artery disease: a randomized, double-blinded, placebo-controlled trial. (2024) ↑
- 5. Impact of Monacolin K-Containing Supplements on Lipid Profile: A Meta-Analysis of Randomised Controlled Trials. (2026) ↑
Generated August 14, 2026
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