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Oleuropein

Oleuropein

Best for

Lower your blood pressure

Faint early signal · 136.2–1000 mg/day for 8 weeks · 1 meta-analysis , n=247

13 papers · 1 claim · 67 outcomes scored · 1 positive

Outcomes

What oleuropein actually does, by outcome

Each row is one outcome with effect size, evidence base, the dose that worked in trials, and time to first effect. Magnitude tiers come from native-unit MCID where available, Cohen's d otherwise.

Outcome Effect Evidence Dose Weeks Rank
Lower your blood pressure Faint early signal
small 		3 meta-analyses n=247 Meta-analyzed 136.2–1000 mg 8 wk —
Buy well

Recommended Oleuropein products

Real products that dose Oleuropein where the research does, in a clean formulation, from brands we've audited. We only list ones we'd stand behind.

Chosen for adequate Oleuropein dosing vs. the studied range, a clean formulation (grade A–C), and independent brand-quality audits. Not sponsored.

Risk profile

Adverse events and known drug interactions

Safety events

mild stomach upset mild
acne
stomach ache
headache
gastrointestinal disorders
musculoskeletal and connective tissue disorders
severe headache
muscle pain

Drug interactions

Ketamine moderate decreases effect
Xylazine moderate decreases effect
Adriamycin moderate increases toxicity
Epirubicin moderate decreases effect
Cyclophosphamide moderate decreases effect
Propofol minor additive

Co-studied with

Supplements that share evidence with oleuropein

Sources

  1. 1. The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial. (2021) ↑
  2. 2. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. (2017) ↑
  3. 3. Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a systematic review and meta-analysis. (2021) ↑
  4. 4. Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial. (2021) ↑
  5. 5. Effects of olive leaf extract supplementation on systemic markers of tissue aging and remodeling in postmenopausal women: a randomized controlled trial with exploratory skin outcomes. (2025) ↑
  6. 6. The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial. (2024) ↑
  7. 7. Efficacy of olive leaves extract on the outcomes of hospitalized covid-19 patients: A randomized, triple-blinded clinical trial. (2023) ↑
  8. 8. Twelve-month consumption of a polyphenol extract from olive (Olea europaea) in a double blind, randomized trial increases serum total osteocalcin levels and improves serum lipid profiles in postmenopausal women with osteopenia. (2015) ↑
  9. 9. Olive Leaf Extract Supplementation Improves Postmenopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Parallel Study on Postmenopausal Women. (2024) ↑
  10. 10. An oleuropein-based dietary supplement may improve joint functional capacity in older people with high knee joint pain: findings from a multicentre-RCT and post hoc analysis. (2022) ↑

Generated August 14, 2026

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